D4505

5,5-Diphenylhydantoin Natriumsalz

≥99%

• Synonym(e): 5,5-Diphenyl-2,4-imidazolidindion, Phenytoin
• Lineare Formel: C₁₅H₁₁N₂O₂Na
• CAS-Nummer: 630-93-3
• Molekulargewicht: 274.25
• EG-Nummer: 211-148-2
• MDL-Nummer: MFCD00069674
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277707
• NACRES: NA.77

Eigenschaften

• Assay: ≥99%
• Form: powder
• Löslichkeit: aqueous base: soluble
• SMILES String: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• InChIKey: FJPYVLNWWICYDW-UHFFFAOYSA-M
• Angaben zum Gen: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

Beschreibung

Allgemeine Beschreibung

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin.[1] 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors.[2] Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.[3]

Anwendung

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds[4]
• in seizure behavior testing as an anticonvulsant in Drosophila[5]
• in in vivo embryo toxicity test in mouse embryonic stem cells[6]

Biochem./physiol. Wirkung

Verringert die Inzidenz von tonisch-klonischen Krampfanfällen; scheint erregbare Membranen zu stabilisieren.

Verringert die Inzidenz von tonisch-klonischen Krampfanfällen; scheint erregbare Membranen, vermutlich durch Effekte auf Na⁺-, K⁺- und Ca²⁺Kanäle, zu stabilisieren.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H317,H361
• P-Sätze: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges