The purification procedure of this product is based on literature references for chymotrypsin A. Therefore, it is believed to be Chymotrypsin A (or Alpha-Chymotrypsin). However, the product is not specifically tested for chymotrypsin B, C, or CTRL, so the presence of B, C, or CTRL cannot be ruled out.
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C8946
α-Chymotrypsin from human pancreas
lyophilized powder
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656,00 €
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1 VIAL
656,00 €
About This Item
656,00 €
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Empfohlene Produkte
Biologische Quelle
human pancreas
Qualitätsniveau
Form
lyophilized powder
Mol-Gew.
25 kDa
Verpackung
vial of ≥10 BTEE units
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... CTRB1(1504)
Verwandte Kategorien
Allgemeine Beschreibung
α-Chymotrypsin belongs to the trypsin family of serine proteases. It is secreted as an inactive precursor chymotrypsinogen to the intestine. The cleavage of peptide bond at amino acid 148 forms α-chymotrypsin.[1] Chymotrypsinogen is encoded by the gene CTRB1 and is mapped to 16q23.1 in the human chromosome.[2]
Anwendung
α-Chymotrypsin from human pancreas has been used to test inhibition by N-alkyl isatins against mammalian serine proteases.[3]
Human α-chymotrypsin has been used in a study to assess the quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin. Human α-chymotrypsin has also been used in a study to investigate the direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry.
Biochem./physiol. Wirkung
A serine protease that hydrolyzes peptide bonds with aromatic or large hydrophobic side chains (Tyr, Trp, Phe, Met) on the carboxyl end of the bond.
Einheitendefinition
One unit will hydrolyze 1.0 μmole of BTEE per min at pH 7.8 at 25°C.
Hinweis zur Analyse
Protein determined by A1%/280
Inhibitor
Produkt-Nr.
Beschreibung
Preisangaben
Substrat
Produkt-Nr.
Beschreibung
Preisangaben
Signalwort
Danger
Gefahreneinstufungen
Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
Mac Sweeney A, et al.
Acta Crystallographica Section D, Biological Crystallography, 56(3), 280-286 (2000)
Parallel synthesis of isatin-based serine protease inhibitors
Shuttleworth SJ, et al.
Bioorganic & Medicinal Chemistry Letters, 10(22), 2501-2504 (2000)
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
Rosendahl J, et al.
Gut, 67(10), 1855-1863 (2018)
Sergey Y Vakhrushev et al.
Molecular & cellular proteomics : MCP, 12(4), 932-944 (2013-02-13)
Characterizing protein GalNAc-type O-glycosylation has long been a major challenge, and as a result, our understanding of this glycoproteome is particularly poor. Recently, we presented a novel strategy for high throughput identification of O-GalNAc glycosites using zinc finger nuclease gene-engineered
Jack C Slootweg et al.
Journal of peptide science : an official publication of the European Peptide Society, 19(11), 692-699 (2013-09-12)
Herein, we describe a scalable purification of the lantibiotic nisin via an extraction/precipitation approach using a biphasic system, which can be carried out up to 40-80 gram scale. This approach results in an at least tenfold enrichment of commercially available
Protokolle
Follow our procedure for the determination of a chymotrypsin activity. This enzymatic assay of alpha chymotrypsin guides you through the entire process and necessary calculations.
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Does product number C8946, which is α-Chymotrypsin from the human pancreas, contain one or both of the three types of chymotrypsin produced by the human pancreas, namely chymotrypsin B form, chymotrypsin C, and the rarer form called "CTRL"?
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