C7505

L-Cystathionin

≥98% (TLC), suitable for UHPLC

• Synonym(e): (R)-S-(2-Amino-2-carboxyethyl)-L-homocystein
• Empirische Formel (Hill-System): C₇H₁₄N₂O₄S
• CAS-Nummer: 56-88-2
• Molekulargewicht: 222.26
• Beilstein: 2505200
• EG-Nummer: 200-295-8
• MDL-Nummer: MFCD00036685
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24892965
• NACRES: NA.26

Eigenschaften

• Produktbezeichnung: L-Cystathionin, ≥98% (TLC)
• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Methode(n): UHPLC: suitable
• Farbe: white
• mp (Schmelzpunkt): >300 °C
• Lagertemp.: −20°C
• SMILES String: N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
• InChI: 1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
• InChIKey: ILRYLPWNYFXEMH-WHFBIAKZSA-N

Beschreibung

Anwendung

L-Cystathionine has been used in ultra-performance liquid chromatography for the validation of cystathionine and the correlation of its abundance with vertebrate metamorphosis. It has also been used as an inhibitor of sinusoidal GSH (glutathione) carrier to signify that thiol redox state imbalance is associated with the modulation of autophagy in carcinoma cells.[1]

Biochem./physiol. Wirkung

L-Cystathionine is an intermediate in the biosynthesis of L-cysteine and methionine.[2][3] It is used as a substrate to differentiate and analyze cystathionine γ-lyase(s).[4] L-Cystathionine is an important non-protein amino acid and is associated with metabolic disorders.[5] In recent studies, L-cystathionine is believed to be the precursor of cyclic imino acid cyclothionine. Cystathioninuria is characterized with imino acid cyclothionine excretion in the urine.[3]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)