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C3138
Kathepsin D aus Rindermilz
lyophilized powder, ≥2.0 units/mg protein
Synonym(e):
CTSD
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5 UNITS
244,00 €
10 UNITS
418,00 €
20 UNITS
829,00 €
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5 UNITS
244,00 €
10 UNITS
418,00 €
20 UNITS
829,00 €
About This Item
CAS-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352204
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
bovine spleen
Assay
10—70% protein (biuret)
Form
lyophilized powder
Spezifische Aktivität
≥2.0 units/mg protein
Mol-Gew.
~45 kDa
Hersteller/Markenname
Sigma-Aldrich
Methode(n)
activity assay: suitable
Farbe
dark brown
Eignung
suitable for molecular biology
UniProt-Hinterlegungsnummer
Anwendung(en)
life science and biopharma
Lagertemp.
−20°C
Angaben zum Gen
cow ... CTSD(282883)
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Allgemeine Beschreibung
Anwendung
Cathepsin D from bovine spleen has been used:
- in in vitro dose-dependent fluorometric activity assays.[3]
- in in vitro myelin oligodendrocyte glycoprotein (MOG) digestion to study the uptake of malondialdehyde (MDA)-modified MOG and its implications in central nervous system autoimmunity.[4]
- for enzymatic digestion of the proteoglycan moiety of the articular cartilage in order to determine its dynamic elastic modulus at two different levels of tissue organization.[5]
- in cathepsin D activity assay.[6]
Biochem./physiol. Wirkung
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts.
Einheitendefinition
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
Physikalische Form
Lyophilized powder containing citrate buffer salts
Inhibitor
Produkt-Nr.
Beschreibung
Preisangaben
Ähnliches Produkt
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Martin Stolz et al.
Biophysical journal, 86(5), 3269-3283 (2004-04-28)
Cartilage stiffness was measured ex vivo at the micrometer and nanometer scales to explore structure-mechanical property relationships at smaller scales than has been done previously. A method was developed to measure the dynamic elastic modulus, |E(*)|, in compression by indentation-type
Olja Mijanovic et al.
Pharmaceutics, 13(6) (2021-07-03)
Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute
Cathepsin D--many functions of one aspartic protease
Benes P, et al.
Critical Reviews in Oncology/Hematology, 68(1), 12-28 (2008)
Marie Maynadier et al.
Journal of controlled release : official journal of the Controlled Release Society, 171(2), 251-257 (2013-08-01)
Implication of the intracellular proteolytic activity of Cathepsin D (CathD), a lysosomal aspartyl-protease overexpressed in numerous solid tumors, has been evidenced on tumor growth. Its intracellular inhibition by potent inhibitors such as pepstatin constitutes a relevant but challenging molecular target.
Daming Chen et al.
Journal of virology, 88(2), 1025-1038 (2013-11-08)
Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Although predominantly lytically expressed, vIL-6 is also produced at
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