A4188

N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin

≥97% (HPLC), powder

• Synonym(e): Ac-IETD-AMC
• Empirische Formel (Hill-System): C₃₁H₄₁N₅O₁₂
• Molekulargewicht: 675.68
• MDL-Nummer: MFCD01630896
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24890834
• NACRES: NA.32

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO/DMF: 1 mg/mL
• Lagertemp.: −20°C
• SMILES String: CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1
• InChI: 1S/C31H41N5O12/c1-6-14(2)26(32-17(5)38)30(46)34-20(9-10-23(39)40)28(44)36-27(16(4)37)31(47)35-21(13-24(41)42)29(45)33-18-7-8-19-15(3)11-25(43)48-22(19)12-18/h7-8,11-12,14,16,20-21,26-27,37H,6,9-10,13H2,1-5H3,(H,32,38)(H,33,45)(H,34,46)(H,35,47)(H,36,44)(H,39,40)(H,41,42)/t14-,16+,20-,21-,26-,27-/m0/s1
• InChIKey: ZYTCBVQZQSFKHQ-HGZCCCDHSA-N
• Angaben zum Gen: human ... CARD8(22900) , CASP8(841) , CASP8AP2(9994) , CFLAR(8837) , GZMB(3002) ; mouse ... CFLAR(117279) , GZMB(171528) ; rat ... CASP8(12370) , CFLAR(12633) , GZMB(14939) , RGD1561819(502004) , RGD1562700(502007)

Beschreibung

Amino Acid Sequence

NAc-Ile-Glu-Thr-Asp-AMC

Anwendung

Fluorogenic substrate for caspase 8 and granzyme B.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)