Some cells, and in particular cancer cells, may be resistant to 5-fluorouracil. Please see this paper Huanwen, W., et al., Molecular Cancer, 8, 125 (2009) which addresses this observation, as well as references 16 and 30 in this publication.If the cells are treated with the closely related gemcitabine (Sigma-Aldrich Product G6423), and cell growth is not inhibited by that drug either, you will have shown that the "problem" is with the cell line, and not with the drug(s).
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PHR1227
Fluorouracil
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(e):
5-Fluorouracil, 2,4-Dihydroxy-5-Fluoropyrimidin, 5-FU, 5-Fluor-2,4(1H,3H)-pyrimidindion
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500 MG
131,00 €
About This Item
Empirische Formel (Hill-System):
C4H3FN2O2
CAS-Nummer:
Molekulargewicht:
130.08
Beilstein:
127172
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24
Empfohlene Produkte
Qualität
certified reference material
pharmaceutical secondary standard
Qualitätsniveau
Agentur
traceable to BP 995
traceable to Ph. Eur. F0250000
traceable to USP 12790000
API-Familie
fluorouracil
Analysenzertifikat (CofA)
current certificate can be downloaded
Methode(n)
HPLC: suitable
gas chromatography (GC): suitable
mp (Schmelzpunkt)
282-286 °C (dec.) (lit.)
Anwendung(en)
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
Format
neat
Lagertemp.
2-30°C
SMILES String
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChIKey
GHASVSINZRGABV-UHFFFAOYSA-N
Angaben zum Gen
human ... TYMS(7298)
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Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.[1]
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.[1]
Anwendung
Fluorouracil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by different analytical techniques.[2][3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Hinweis zur Analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Sonstige Hinweise
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Fußnote
To see an example of a Certificate of Analysis for this material enter LRAC3468 in the slot below. This is an example certificate only and may not be the lot that you receive.
Empfohlene Produkte
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Ähnliches Produkt
Produkt-Nr.
Beschreibung
Preisangaben
Fluorouracil-verwandte Verbindung A, certified reference material, pharmaceutical secondary standard
Fluorouracil-verwandte Verbindung B, pharmaceutical secondary standard, certified reference material
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 3 Oral - Carc. 2
Lagerklassenschlüssel
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Hier finden Sie alle aktuellen Versionen:
Analysenzertifikate (COA)
Lot/Batch Number
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5-fluorouracil (5-FU) remains the cornerstone of all currently applied regimens for the treatment of patients with cancers of the gastrointestinal tract, breast, and head and neck. Unfortunately, a large variation in the clearance of 5-FU has been observed between patients
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Why does the 5-Fluorouracil have no effect on my cell line, even at micromolar concentrations that should be more than high enough?
1 Antwort-
Hilfreich?
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Do you have 5-FU (5-Fluorouracil) for injection? If not, how can I prepare it from the powder?
1 Antwort-
Sigma-Aldrich lists several fluorouracil products, but we do not offer Fluorouracil for injection. Our 5-Fluorouracil (5-FU) products cannot be given to human patients. (Note that although Product F8423 meets USP testing specifications, it is not a pharmaceutical grade or PharmaGrade product.)Having said that, a solution for injection into research animals could be prepared the same way as the Fluorouracil Injection, USP is. According to the drugs.com, "Fluorouracil Injection, USP, an antineoplastic anti-metabolite, is a colorless to yellow aqueous sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains: 50 mg fluorouracil; pH is adjusted to 8.6 to 9.4 with sodium hydroxide".
Hilfreich?
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What is the Department of Transportation shipping information for this product?
1 Antwort-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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