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Sigma-Aldrich

Methylglyoxal -Lösung

technical, ~40% in H2O

Synonym(e):

Acetylformaldehyd, Pyruvaldehyd

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About This Item

Lineare Formel:
CH3COCHO
CAS-Nummer:
78-98-8
Molekulargewicht:
72.06
Beilstein:
906750
MDL-Nummer:
MFCD00006960
UNSPSC-Code:
12352100
PubChem Substanz-ID:
329760261
NACRES:
NA.22

Qualität

technical

Qualitätsniveau

200

Konzentration

~40% in H2O

Dichte

1.19 g/mL at 20 °C

Lagertemp.

2-8°C

SMILES String

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChIKey

AIJULSRZWUXGPQ-UHFFFAOYSA-N

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Allgemeine Beschreibung

Methylglyoxal is a toxic endogenous by-product of glycolysis. It is a reactive dicarbonyl compound that promotes non-enzymatic glycation of proteins to yield irreversible advanced glycated end products, leading to the cross-linking or degradation of proteins.

Anwendung

Methylglyoxal solution is used in cytotoxic studies.

Signalwort

Danger

Gefahreneinstufungen

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Analysenzertifikate (COA)

Lot/Batch Number
WXBF4459V
WXBF3145V
BCCJ9027
BCCL0658
BCCH4313

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Potential Neuroprotective and Anti-Apoptotic Properties of a Long-Lasting Stable Analog of Ghrelin: an In Vitro Study Using SH-SY5Y Cells.
Popelova A, et al.
Physiological Research, 67(2), 339-346 (2018)
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
Drug Development Research, 79(2), 58-69 (2018)
Nicole Schupp et al.
Annals of the New York Academy of Sciences, 1043, 685-695 (2005-07-23)
In patients with chronic renal failure, cancer incidence is increased. This may be related to an elevated level of genomic damage, which has been demonstrated by micronuclei formation as well as by comet assay analysis. Advanced glycation end products (AGEs)
Naila Ahmed et al.
Investigative ophthalmology & visual science, 44(12), 5287-5292 (2003-11-26)
To determine the concentrations of methylglyoxal-derived advanced glycation end-products (AGEs), the hydroimidazolones MG-H1 and -H2, in soluble human lens proteins and compare them with the concentrations of other methylglyoxal-derived AGEs and pentosidine. Lens protein samples were hydrolyzed enzymatically. AGEs were
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