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Supelco

Staurosporin

VETRANAL®, analytical standard

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About This Item

Empirische Formel (Hill-System):
C28H26N4O3
CAS-Nummer:
62996-74-1
Molekulargewicht:
466.53
MDL-Nummer:
MFCD00077402
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329755625
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Produktlinie

VETRANAL®

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Lagertemp.

−20°C

SMILES String

CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1

InChIKey

HKSZLNNOFSGOKW-ZGQXJOJZSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

Staurosporin gehört zur Klasse der Indolcarbazolalkaloide und weist antimykotische und antioomykotische Wirkungen auf. Es wird aus Streptomyces sp. isoliert und ist ein Breitspektruminhibitor von Proteinkinase.

Anwendung


  • Protein Painting for Structural Analysis: This research utilizes staurosporine′s role in protein kinase inhibition to develop a technique called protein painting, which is essential for structural and binding site analysis. This approach enhances understanding of protein interactions and can be pivotal in drug design, particularly in targeting specific kinase enzymes in cancer research (Zheng Z et al., 2024).

  • Identification of Anthelmintic Activities: Staurosporine is employed to identify small molecule inhibitors that target conserved proteins among gastrointestinal nematodes. This study not only highlights its role in parasitic infection treatments but also its broader applications in developing antiparasitic drugs, leveraging its properties as a potent kinase inhibitor (Jung H et al., 2024).

  • Development of Novel Cytoprotective Compounds: Focusing on mitochondria-dependent cell death, this research explores staurosporines potential to inhibit pathways involved in cellular apoptosis. This is particularly crucial in developing therapeutic strategies against diseases characterized by unwanted cell death, such as neurodegenerative diseases and certain types of cancer (Matsuyama M et al., 2023).

Sonstige Hinweise

Weitere Informationen zur geeigneten Instrumententechnik finden Sie im Analysenzertifikat des Produkts. Weitere Unterstützung erhalten Sie vom technischen Kundendienst.

Rechtliche Hinweise

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H361d,H413

Gefahreneinstufungen

Aquatic Chronic 4 - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
BCCJ6830
BCCH5171
BCCF1431
BCCC2217
BCBX0018

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Die Dokumentenbibliothek aufrufen

Karin Anestål et al.
PloS one, 3(4), e1846-e1846 (2008-04-03)
SecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C-terminal truncation. SecTRAPs are devoid of thioredoxin reductase activity but
A Gescher
General pharmacology, 31(5), 721-728 (1998-11-11)
1. Protein kinase C (PKC) is a family of serine/threonine-directed protein kinases that are pivotal regulators of cellular growth, transformation and death. PKC has therefore been considered to be a suitable target for novel antineoplastic drugs. 2. Twenty years ago
S Ståhl et al.
Cell death & disease, 4, e454-e454 (2013-01-11)
Radiation therapy is frequently used to treat non-small cell lung cancers (NSCLCs). We have previously shown that a combination of ionizing radiation (IR) and the staurosporine analog PKC 412, but not Ro 31-8220, increases cell death in NSCLC cells. To
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
U T Rüegg et al.
Trends in pharmacological sciences, 10(6), 218-220 (1989-06-01)
Karolien De Bosscher et al.
Cellular and molecular life sciences : CMLS, 71(1), 143-163 (2013-06-21)
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with the activity of pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This mechanism is believed to involve the activity of GR monomers. Here, we
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