5.05026

DNQX Disodium Salt

• Synonym(e): DNQX Disodium Salt, AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX
• Empirische Formel (Hill-System): C₈H₂N₄Na₂O₆
• CAS-Nummer: 2379-57-9
• Molekulargewicht: 296.10
• MDL-Nummer: MFCD00069257
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥99% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: dark brown
• Löslichkeit: H₂O: 100 mM
• Lagertemp.: 2-8°C
• SMILES String: [N+](=O)([O-])c1cc2[nH][c]([c]([nH]c2cc1[N+](=O)[O-])=O)=O
• InChI: 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
• InChIKey: RWVIMCIPOAXUDG-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC₅₀ = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.

Biochem./physiol. Wirkung

Primary Target
AMPA

Secondary Target
GluK2

Target IC₅₀: 0.19 to 1.66 uM

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
Honor, T., et al. 1998. Science.241, 701.
Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49.
Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable