860514P

C14 Ceramide (d18:1/14:0)

Avanti Research^™ - A Croda Brand 860514P, powder

• Synonym(e): N-myristoyl-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₃₂H₆₃NO₃
• CAS-Nummer: 123408-74-2
• Molekulargewicht: 509.85
• MDL-Nummer: MFCD01320386
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 25 mg (860514P-25mg); pkg of 1 × 5 mg (860514P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860514P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1
• InChIKey: ZKRPGPZHULJLKJ-JHRQRACZSA-N

Beschreibung

Allgemeine Beschreibung

Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids.[1] The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi.[1] Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramide.[2]

Anwendung

C14 Ceramide (d18:1/14:0) is suitable for use

• as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS²) for ceramide quantification from muscel biopsies[3]
• in lipid monolayer preparation for biophysical studies[4]
• in the morphological and dimensional evaluation studies[5]

Biochem./physiol. Wirkung

Ceramides regulate biological processes including proliferation, differentiation and apoptosis.[5] In the cystic fibrosis patients, elevated levels of C14 ceramide is observed.[1] It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio.[6] Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.[2]

Verpackung

5 mL Amber Glass Screw Cap Vial (860514P-25mg)

5 mL Amber Glass Screw Cap Vial (860514P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids