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810340P

Avanti

Click PI(4,5)P2-azido

Avanti Research™ - A Croda Brand 810340P, powder

Synonym(e):

1-oleoyl-2-(6-(6-azidohexanoyl)aminohexanoyl)-sn-glycero-3-phosphoinositol-4.5-bisphosphate (ammonium salt)

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100 μG
317,00 €

317,00 €

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100 μG
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About This Item

Empirische Formel (Hill-System):
C39H82N7O20P3
CAS-Nummer:
2260669-67-6
Molekulargewicht:
1062.02
MDL-Nummer:
MFCD00037705
UNSPSC-Code:
12352211
NACRES:
NA.25

317,00 €

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Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 100 μg (with stopper and crimp cap (810340P-100ug))

Hersteller/Markenname

Avanti Research™ - A Croda Brand 810340P

Lipid-Typ

click reagents

Versandbedingung

dry ice

Lagertemp.

−20°C

Verwandte Kategorien

Allgemeine Beschreibung

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an anionic lipid [1] and is present in the plasma membrane (PM).[2]

Biochem./physiol. Wirkung

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a lipid messenger. It controls exocytosis, actin cytoskeleton dynamics and endocytosis.[3] It also plays a key role in signal transduction, vesicle trafficking and motility.[4] The azido functional group in the lipid may involve in a copper-catalyzed reaction to form click reaction.[5]

Verpackung

2 mL Amber Serum Vial with Stopper and Crimp Cap (810340P-100ug)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

Clickable lipids: azido and alkynyl fatty acids and triacylglycerols
Zerkowski JA, et al.
Journal of the American Oil Chemists' Society, 86(11), 1115-1115 (2009)
Xiaojun Tan et al.
Journal of cell science, 128(22), 4047-4056 (2015-11-18)
Phosphoinositides are a collection of lipid messengers that regulate most subcellular processes. Amongst the seven phosphoinositide species, the roles for phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at the plasma membrane, such as in endocytosis, exocytosis, actin polymerization and focal adhesion assembly, have been
Analysis of Phosphatidic Acid Binding and Regulation of PIPKI In Vitro and in Intact Cells
Methods in Enzymology, 583, 359-374 (2017)
Arne Gericke et al.
Advances in experimental medicine and biology, 991, 85-104 (2013-06-19)
PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) is a relatively common anionic lipid that regulates cellular functions by multiple mechanisms. Hydrolysis of PtdIns(4,5)P2 by phospholipase C yields inositol trisphosphate and diacylglycerol. Phosphorylation by phosphoinositide 3-kinase yields PtdIns(3,4,5)P3, which is a potent signal for survival
Mira Sohn et al.
The Journal of cell biology, 217(5), 1797-1813 (2018-02-24)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how cells regulate PM PI(4,5)P2 levels. Here, we show that the phosphatidylinositol 4-phosphate (PI4P)/phosphatidylserine (PS) transfer activity of the endoplasmic reticulum

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