T101

Gaboxadol -hydrochlorid

solid, ≥98% (HPLC)

• Synonym(e): 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride, THIP hydrochloride
• Empirische Formel (Hill-System): C₆H₈N₂O₂ · HCl
• CAS-Nummer: 85118-33-8
• Molekulargewicht: 176.60
• EG-Nummer: 285-687-7
• MDL-Nummer: MFCD00055180
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57654649
• NACRES: NA.22

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Farbe: white
• Löslichkeit: ethanol: 0.91 mg/mL; H₂O: 20 mg/mL
• SMILES String: Cl[H].Oc1noc2CNCCc12
• InChI: 1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
• InChIKey: ZDZDSZQYRBZPNN-UHFFFAOYSA-N
• Angaben zum Gen: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Beschreibung

Allgemeine Beschreibung

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors.[1][2] Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia[3] and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.[4]

Anwendung

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.[5]

Biochem./physiol. Wirkung

GABA_A receptor agonist.

Vorsicht

Photosensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)