6-Azidohexanoic acid is a six-carbon saturated fatty acid with an ω-terminal azide group. This building block can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC), forming a stable amide bond. The terminal azide group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is useful for crosslinking, synthesis of chemical probes, and other bioconjugation strategies.
Conception of Stretchable Resistive Memory Devices Based on Nanostructure?Controlled Carbohydrate?block?Polyisoprene Block Copolymers.
Hung C C, et al.
Advances in Functional Materials, 27(13) (2017)
Activated Microglia Targeting Dendrimer?Minocycline Conjugate as Therapeutics for Neuroinflammation.
Sharma R, et al.
Bioconjugate Chemistry, 28(11), 2874-2886 (2017)
CuAAC macrocyclization: high intramolecular selectivity through the use of copper?tris (triazole) ligand complexes.
Chouhan G and James K
Organic Letters, 13(10), 2754-2757 (2011)
Efficient Access to New Chemical Space Through Flow?Construction of Druglike Macrocycles Through Copper?Surface?Catalyzed Azide?Alkyne Cycloaddition Reactions.
Bogdan A R and James K
Chemistry?A European Journal , 16(48), 14506-14512 (2010)
Well-defined dendronized cellulose substrates displaying multiple representations of dual-functionality were constructed by taking advantage of the efficiency of the click reaction combined with traditional anhydride chemistry. First, activated cellulose surfaces were decorated with several generations of dendrons, and their peripheral
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