335452

Lithium(trimethylsilyl)acetylid -Lösung

0.5 M in THF

• Synonym(e): Trimethylsilylethinyl-lithium
• Lineare Formel: (CH₃)₃SiC≡CLi
• CAS-Nummer: 54655-07-1
• Molekulargewicht: 104.15
• Beilstein: 3587411
• MDL-Nummer: MFCD00075059
• UNSPSC-Code: 12352103
• PubChem Substanz-ID: 24860321
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Qualitätsniveau: 100
• Konzentration: 0.5 M in THF
• Dichte: 0.88 g/mL at 25 °C
• SMILES String: [Li]C#C[Si](C)(C)C
• InChI: 1S/C5H9Si.Li/c1-5-6(2,3)4;/h2-4H3;
• InChIKey: ZVXXEONXFWSCIZ-UHFFFAOYSA-N

Beschreibung

Anwendung

Packaged in Sure/Seal^® bottles

Lithium (trimethylsilyl)acetylide can be used as a reagent:

• In the transmetalation and nucleophilic displacement reactions.[1]
• To prepare propargylic alcohol derivatives by reacting with aldehydes and ketones.[1]
• To synthesize α,βynones by treating with Weinreb amide or with isoxazolidide.[1]
• Along with Grignard reagent to convert γ- and δ-thiolactams to thioiminium salts, which are employed as key intermediates to produce disubstituted pyrrolidines.[2]

Verpackung

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Rechtliche Hinweise

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302,H314,H335,H336,H351
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Zielorgane: Respiratory system
• Zusätzliche Gefahrenhinweise: EUH019
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): -9.4 °F - closed cup
• Flammpunkt (°C): -23 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter