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258385

Sigma-Aldrich

Protoporphyrin IX Dinatriumsalz

≥90% (HPLC)

Synonym(e):

3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphindipropionsäure Dinatriumsalz, Depocolin-S, Ooporphyrin Dinatriumsalz

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250 MG
57,10 €
1 G
195,00 €
5 G
644,00 €

About This Item

Empirische Formel (Hill-System):
C34H32N4Na2O4
CAS-Nummer:
Molekulargewicht:
606.62
Beilstein:
5227034
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352103
PubChem Substanz-ID:
NACRES:
NA.23

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Qualitätsniveau

Assay

≥90% (HPLC)

Form

powder

λmax

406 nm

Lagertemp.

2-8°C

SMILES String

[Na+].[Na+].Cc1c(CCC([O-])=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC([O-])=O

InChI

1S/C34H34N4O4.2Na/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16,36-37H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);;/q;2*+1/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

InChIKey

JZRNDUPVNXWZDY-HXFTUNQESA-L

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Anwendung

Protoporphyrin disodium salt (PpIX) was used as a dye content for fluorescence spectroscopic characterization in a study. [1] The cytotoxic effect of PpIX on sarcoma 180 solid tumors cells was reported in a study. [2][3]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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PloS one, 7(11), e50082-e50082 (2012-11-29)
Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide transporter-1 and -2, ferrochelatase and ATP-binding cassette transporter G2
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Fragen

1-2 von 2 Fragen  
  1. To study interaction of porphyrin with a protein, how should a solution of this compound be made for flourescence quenching?

    1 Antwort
    1. This is not an application that is tested internally, but there is evidence in literature (Iwunze MO. The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX). Material Sci & Eng. 2022;6(3):97‒99. DOI: 10.15406/mseij.2022.06.00185) that concentrations between 6.45 x 10-7 M to 3.24 x 10-6 M PPIX are effective for quenching. Another author describes the quenching of protein fluorescence by PPIX by using a solution concentration range of 1×10−5 M to 3×10−4 M excited at 280 nm and 1x10−5 M to 3×10−4 M excited at 295 nm (Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking, Molecules 2016, 21(11), 1519).

      Hilfreich?

  2. What is the water solubility of PPIX-disodium?

    1 Antwort
    1. This chemical is known to be soluble in chloroform or methanol and slightly soluble in water. The concentration at which this product is solubilized is not determined.

      Hilfreich?

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