1568040

Proguanil hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonyma: Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• Empirický vzorec (Hillův zápis): C₁₁H₁₆ClN₅·HCl
• Číslo CAS: 637-32-1
• Molekulová hmotnost: 290.19
• MDL number: MFCD01732193
• UNSPSC Code: 41116107
• PubChem Substance ID: 329750967
• NACRES: NA.24

Vlastnosti

• grade: pharmaceutical primary standard
• API family: proguanil
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• InChI key: SARMGXPVOFNNNG-UHFFFAOYSA-N

Popis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Proguanil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable