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V2264

Sigma-Aldrich

Vinorelbine ditartrate salt hydrate

≥98% (HPLC), powder

Synonyma:

3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate

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About This Item

Empirický vzorec (Hillův zápis):
C45H54N4O8 · 2C4H6O6 · xH2O
Číslo CAS:
125317-39-7
Molekulová hmotnost:
1079.11 (anhydrous basis)
MDL number:
MFCD03613607
UNSPSC Code:
12352200
PubChem Substance ID:
24724660
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H2O: 10 mg/mL

originator

Pierre Fabre

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[H]O[H].O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@]12C[N@H](CC(CC)=C1)Cc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC

InChI

1S/C45H54N4O8.2C4H6O6.H2O/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10;/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10);1H2/t28-,37-,38+,39+,42+,43+,44-,45-;2*1-,2-;/m011./s1

InChI key

ZLIPKSVXTCRHIB-GNBHHJMASA-N

Biochem/physiol Actions

Vinorelbine is a potent anti-mitotic, anti-tumor agent. Vinorelbine inhibits microtubule assembly. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules.

Features and Benefits

This compound was developed by Pierre Fabre. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Hongyang Li et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 89, 1277-1285 (2017-03-23)
Vinorelbine (NVB) is a semi-synthetic vinca alkaloid that is approved for the clinical therapy of lung cancer. However, the clinical application of NVB was limited because of the acquisition of resistance and inacceptable toxicity. Therefore, it is of great interest
Juliana Teixeira Fiquer et al.
Journal of affective disorders, 238, 636-644 (2018-06-30)
It is unclear if individuals with Major Depressive Disorder (MDD) present different nonverbal behavior (NVB) compared with healthy individuals, and also if depression treatments affect NVB. In this study, we compared the NVB of MDD subjects and healthy controls. We
Lihui Wang et al.
Cell death & disease, 8(4), e2746-e2746 (2017-04-14)
Chemotherapeutic agents are generally used as a frontline therapy for non-small cell lung cancer (NSCLC). However, resistance to chemotherapy arises rapidly in NSCLC, and the reasons for chemotherapy resistance have not been fully determined. Here, we found cisplatin, but not
Fabio Castiglione et al.
Current urology reports, 18(11), 90-90 (2017-10-02)
Due to the increasing numbers of radical prostatectomies (RP) performed for prostate cancer, a substantial number of patients are now suffering from post-operative erectile dysfunction (ED). The aim of this study is to summarize the current literature on surgical techniques
Vural Tagal et al.
Cancer research, 81(2), 400-413 (2020-11-12)
Polyploid giant cancer cells (PGCC) are common in tumors and have been associated with resistance to cancer therapy, tumor relapse, malignancy, immunosuppression, metastasis, cancer stem cell production, and modulation of the tumor microenvironment. However, the molecular mechanisms that cause these
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