T0577

D-δ-Tocotrienol

from rice, ≥65% (GC)

• Synonyma: (R-(E,E))-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
• Empirický vzorec (Hillův zápis): C₂₇H₄₀O₂
• Číslo CAS: 25612-59-3
• Molekulová hmotnost: 396.61
• UNSPSC Code: 12352205
• NACRES: NA.79

Vlastnosti

• biological source: rice
• Quality Level: 100
• form: liquid
• concentration: ≥65% (GC)
• color: yellow to orange
• storage temp.: −20°C
• SMILES string: O1[C@@](CCc2c1c(cc(c2)O)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
• InChI: 1S/C27H40O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h10,12,14,18-19,28H,7-9,11,13,15-17H2,1-6H3/b21-12+,22-14+/t27-/m1/s1
• InChI key: ODADKLYLWWCHNB-LDYBVBFYSA-N

Popis

General description

D-δ-Tocotrienol is a bioavailable isomer of vitamin E and has farnesyl side chain. Palm oil is rich in δ-Tocotrienol.

Biochem/physiol Actions

D-δ-Tocotrienol suppresses ras sarcoma (Ras) protein levels. It elicits anti-proliferative functionality in melanoma cells by halting cell cycle and favoring apoptosis. δ-Tocotrienol is cytotoxic to human lung adenocarcinoma and glioblastoma cancer cells. δ-Tocotrienol possesses anti-inflammatory, antidiabetic and neuroprotective functionality. It is an effective hypocholesterolemic agent and an inhibitor of lipid peroxidation.

Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. δ-tocotrienol, effectively blocks cleavage of SREBPs, ultimately decreasing the amount of cholesterol synthesized in the liver.

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)