SRP6508

Haptoglobin (Phenotype 2-2) from human plasma

≥95% (SDS-PAGE)

• Synonyma: Hp 2-2
• UNSPSC Code: 12352202
• NACRES: NA.32

Vlastnosti

• biological source: human plasma
• assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: 170-900 kDa
• packaging: pkg of 1 mg
• UniProt accession no.: P00738
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... HP(3240)

Popis

General description

Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.

Application

Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.

Biochem/physiol Actions

Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.

Physical form

Lyophilized as a salt-free solid.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable