SML3808

Firategrast

≥98% (HPLC)

• Synonyma: SB 683699, T 0047, T-0047, (αS)-α-[(2,6-Difluorobenzoyl)amino]-4′-(ethoxymethyl)-2′,6′-dimethoxy[1,1′-biphenyl]-4-propanoic acid, (S)-2-(2,6-Difluorobenzamido)-3-(4′-(ethoxymethyl)-2′,6′-dimethoxy-[1,1′-biphenyl]-4-yl)propanoic acid, SB-683699
• Empirický vzorec (Hillův zápis): C₂₇H₂₇F₂NO₆
• Číslo CAS: 402567-16-2
• Molekulová hmotnost: 499.50
• UNSPSC Code: 51111800
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Popis

Biochem/physiol Actions

Firategrast is an orally available, potent and selective antagonist of α4β1/α4β7 integrins. Firategrast inhibits α4β1/α4β7 integrin-mediated transferring of lymphocytes into the central nervous system (CNS). In phase II trial it demonstrated a reduction of new contrast enhancing MRI lesions in patients with relapsing remitting MS.

Orally available, potent and selective antagonist of α4β1/α4β7 integrins

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable