Přejít k obsahu
Merck
Všechny fotografie(1)

Hlavní dokumenty

Zobrazit celou dokumentaci

I2778

Sigma-Aldrich

IL-1α human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyma:

IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Všechny fotografie(1)

About This Item

MDL number:
MFCD00164814
UNSPSC Code:
12352202
NACRES:
NA.77

Název produktu

Interleukin-1α human, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

quality

endotoxin tested

mol wt

~17 kDa

packaging

pkg of 2 and 10 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01583

storage temp.

−20°C

Gene Information

human ... IL1A(3552)

General description

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

Application

Interleukin-1α (IL-1α) has been used:
  • to study its effects on human colorectal adenocarcinoma cells
  • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
  • to pre-stimulate human THP-1 monocytes

Biochem/physiol Actions

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

Physical form

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

Analysis Note

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number
0000309419
SLCQ8845
0000252244
SLCN6412
SLCP6279

Nevidíte správnou verzi?

Potřebujete-li konkrétní verzi, můžete vyhledat daný certifikát podle čísla dávky nebo čísla šarže.

Vyhledat COA

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Nelson C Di Paolo et al.
Nature immunology, 17(8), 906-913 (2016-07-21)
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α)
Peleg Rider et al.
Seminars in immunology, 25(6), 430-438 (2013-11-05)
Although the IL-1α molecule has long been recognized, information about its distinct role in various diseases is limited, since most clinical studies have focused on the role of IL-1β. Despite triggering the same IL-1 receptor as does IL-1β, there is
Association of interleukin1 beta, interleukin1 receptor antagonist, interleukin 6 and angiotensin II receptor type I gene polymorphisms with end stage renal disease: A meta-analysis
Divya M, et al.
Gene Reports, 100856-100856 (2020)
Niklas Palmqvist et al.
Journal of inflammation (London, England), 13, 20-20 (2016-06-25)
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects and safety concerns associated with these agents restrict their use, and new, safe treatment
Romain Duroux et al.
International journal of cosmetic science, 44(6), 614-624 (2022-08-19)
A critical and often-overlooked factor that may give rise to dandruff and oily hair is the intrinsic quality of the scalp stratum corneum (SC), which is often unbalanced and susceptible to external aggressions. Addressing the inflammation element of unhealthy scalp
Zobrazit všechny související dokumenty

Sortimentní položky

Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.