SML3373

BZ194

≥98% (HPLC)

• Synonyma: 3-Carboxy-1-[2-(octylamino)-2-oxoethyl]pyridinium bromide, 3-Carboxy-1-octylcarbamoylmethyl-pyridinium bromide, BZ 194, BZ-194
• Empirický vzorec (Hillův zápis): C₁₆H₂₅BrN₂O₃
• Číslo CAS: 936356-28-4
• Molekulová hmotnost: 373.29
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C[N+]1=CC(C(O)=O)=CC=C1)NCCCCCCCC.[Br-]

Popis

Biochem/physiol Actions

BZ194 is a selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to type 1 ryanodine receptor (RYR-1; IC50 ~10 uM against 1 uM NAADP). BZ194 inhibits Ca(2+) mobilization induced by NAADP (IC50 ~3 uM co-injected with 100 nM NAADP into Jurkat T cells), but not Ins(1,4,5)P3 or cyclic ADP-ribose (cADPR), and exhibits no inhibitory potency against capacitative Ca(2+) entry.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable