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Key Documents

SAB2500814

Sigma-Aldrich

Anti-PPP1R15A/GADD34 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyma:

Anti-GADD34, Anti-Growth arrest and DNA-damage-inducible 34, Anti-Protein phosphatase 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

O75807

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PPP1R15A(23645)

General description

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) or growth arrest and DNA-damage-inducible 34 (GADD34) is the regulatory subunit of eukaryotic translation initiation factor 2 (eIF2α) phosphatase. It is expressed when there is a signal indicating endoplasmic reticulum stress. The PPP1R15A gene is localized on human chromosome 19q13.33.

Immunogen

Peptide with sequence C-AAALDLSGRRG from the C Terminus of the protein sequence according to NP_055145.2.

Biochem/physiol Actions

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) recruits and regulates the α-subunit of protein phosphatase 1 (PP1). It functions as a stress marker. When there is depletion in amino acid levels in the cell, PPP1R15A is expressed in high concentrations. It regulates the mammalian target of rapamycin (mTOR) pathway and thereby boosts autophagy in macrophages. Studies have shown that PPP1R15A is expressed in the oligodendrocytes of patients suffering from Alzheimer′s disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Increased GADD34 in oligodendrocytes in Alzheimer's disease.
Honjo Y, et al.
Neuroscience Letters, 602, 50-55 (2015)
Yasuyuki Honjo et al.
Neuroscience letters, 602, 50-55 (2015-07-06)
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) and abnormally phosphorylated tau which contribute to endoplasmic reticulum (ER) stress. Previous studies demonstrated that Aβ and a truncated fragment of Aβ induced death of oligodendrocytes in vitro. In
Wei Zhou et al.
The Journal of biological chemistry, 288(46), 33146-33155 (2013-10-05)
In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation of GADD34 assembles an eIF2α phosphatase that feeds back to restore mRNA translation. Active proteasomal
Oliver Kepp et al.
Cell cycle (Georgetown, Tex.), 8(23), 3971-3977 (2009-11-11)
In response to some chemotherapeutic agents, tumor cells can translocate calreticulin (CRT), which is usually contained in the lumen of the endoplasmic reticulum, to the surface of the plasma membrane. This effect requires the phosphorylation of the eukaryotic initiation factor
Motonao Nakao et al.
Oncology reports, 25(6), 1603-1611 (2011-04-07)
The aim of the present study was to investigate the chromosomal aberrations that are linked with the crucial clinicopathological features of colorectal cancer (CRC) and its prognosis by array-based comparative genomic hybridization (CGH). Fresh-frozen tumor tissues of 94 cases of
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