SAB1103260

Anti-DCAF15 (567-580) antibody produced in rabbit

IgG fraction of antiserum

• Synonyma: Anti-C19orf72, Anti-DDB1 and CUL4 associated factor 15
• UNSPSC Code: 12352203
• NACRES: NA.41

Vlastnosti

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~66 kDa
• species reactivity: human
• technique(s): western blot: 1:500-1:2,000
• UniProt accession no.: Q66K64
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... DCAF15(90379)

Popis

General description

DCAF15 (DNA damage binding protein1 (DDB1) and cullin4 (CUL4) associated factor 15) gene in human chromosome, is mapped to 19p13.12. DCAF15 lacks protein interaction domain.

DCAF15 protein is a substrate receptor for E3 ligase. This protein is a part of the cullin 4-RING (CRL4)-DCAF15 E3 ubiquitin ligase.

Immunogen

synthetic peptide corresponding to amino acids 567-580 of human DCAF15

Application

Anti-DCAF15 (567-580) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

DCAF15 (DNA damage binding protein 1 (DDB1) and cullin4 (CUL4) associated factor 15) is the vertebrate ortholog of Saccharomyces pombe chromosome licensing and DNA replication factor 2 (Cdt2) and is required for destruction of Cdt1 during S phase and after DNA damage in human cells.

DCAF15 protein plays a role in RNA splicing and cell apoptosis of various cancer cell lines. This protein is also involved in ubiquitination and degradation of splicing factor RNA binding motif protein 39 (RBM39).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable