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S5576

Sigma-Aldrich

SKA-31

≥98% (HPLC)

Synonyma:

Naphtho[1,2-d]thiazol-2-ylamine

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

Empirický vzorec (Hillův zápis):
C11H8N2S
Číslo CAS:
40172-65-4
Molekulová hmotnost:
200.26
MDL number:
MFCD00051329
UNSPSC Code:
12352202
PubChem Substance ID:
329824457
NACRES:
NA.25

assay

≥98% (HPLC)

form

solid

solubility

DMSO: ≥30 mg/mL

storage temp.

−20°C

SMILES string

Nc1nc2c(ccc3ccccc23)s1

InChI

1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)

InChI key

FECQXVPRUCCUIL-UHFFFAOYSA-N

Biochem/physiol Actions

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Alexander I Bondarenko et al.
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Lysophosphatidylinositol (LPI) and lysophosphatidylcholine (LPC) are lipid signaling molecules that induce endothelium-dependent vasodilation. In addition, LPC suppresses acetylcholine (Ach)-induced responses. We aimed to determine the influence of LPC and LPI on hyperpolarizing responses in vitro and in situ endothelial cells
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Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2018-07-11)
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International journal of molecular sciences, 20(17) (2019-08-28)
The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance calcium-activated potassium channels, and to evaluate its influence on endothelium-derived hyperpolarization (EDH)-KCa2.3/KCa3.1 type relaxation in isolated endothelium-intact
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