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R4653

Sigma-Aldrich

Anti-hnRNP-A2/B1 antibody, Mouse monoclonal

clone DP3B3, purified from hybridoma cell culture

Synonyma:

Anti-Heterogeneous Nuclear Ribonucleoprotein-A2/B1

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About This Item

MDL number:
MFCD03845440
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DP3B3, monoclonal

form

buffered aqueous solution

mol wt

antigen ~36 kDa

species reactivity

rat, human, bovine, hamster, monkey, chicken, mouse, canine

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract from 293T cell line

isotype

IgG2a

UniProt accession no.

P22626

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HNRNPA2B1(3181)
mouse ... Hnrnpa2b1(53379)
rat ... Hnrnpa2b1(362361)

General description

Monoclonal Anti-hnRNP-A2/B1 (mouse IgG2a isotype) is derived from the DP3B3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with recombinant human hnRNP-A2. hnRNP-A2/B1 proteins are located in the nucleus of most tissues cells. However, the hnRNP-A2 protein is found also in the cytoplasm of skin and esophagus cells. In rat brain, hnRNP-A2/B1 proteins are found in neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamin and the supraoptic nucleus of the hypothalamus.

Immunogen

recombinant human hnRNP-A2.

Application

Monoclonal Anti-hnRNP-A2/B1 antibody produced in mouse been used in :
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry

Biochem/physiol Actions

In cells, it actively participates in pre-messenger RNA (pre-mRNA) processing, mRNA metabolism and transportation. It is overexpressed in the initial stage of lung cancer and in premalignant lesions. It also participates in neurodegeneration mediated by rCGG (repeats).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Navštívit knihovnu dokumentů

RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS
Sofola OA, et al.
Neuron, 55(4), 565-571 (2007)
Immunohistochemical study of the hnRNP A2 and B1 in the rat forebrain
Mizukami K, et al.
Neuroreport, 11(14), 3099-3102 (2000)
Rocio Bengoechea et al.
Human molecular genetics, 24(23), 6588-6602 (2015-09-13)
Limb-girdle muscular dystrophy type 1D (LGMD1D) is caused by dominantly inherited missense mutations in DNAJB6, an Hsp40 co-chaperone. LGMD1D muscle has rimmed vacuoles and inclusion bodies containing DNAJB6, Z-disc proteins and TDP-43. DNAJB6 is expressed as two isoforms; DNAJB6a and
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Molecular cancer therapeutics, 14(8), 1884-1895 (2015-06-10)
Castration-resistant prostate cancer (CRPC) remains dependent on androgen receptor (AR) signaling. Alternative splicing of the AR to generate constitutively active, ligand-independent variants is one of the principal mechanisms that promote the development of resistance to next-generation antiandrogens such as enzalutamide.
Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival
Deng J, et al.
Molecular Neurobiology, 53(2), 1132-1144 (2016)
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