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PZ0114

Sigma-Aldrich

PD-166866

≥98% (HPLC)

Synonyma:

1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea

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About This Item

Empirický vzorec (Hillův zápis):
C20H24N6O3
Číslo CAS:
192705-79-6
Molekulová hmotnost:
396.44
MDL number:
MFCD12922514
UNSPSC Code:
51111800
PubChem Substance ID:
329823706
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

color

off-white to light tan

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C

InChI

1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)

InChI key

NHJSWORVNIOXIT-UHFFFAOYSA-N

Biochem/physiol Actions

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number
0000376719
0000376719
0000269567
0000269567
0000128581

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Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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