P1034

Phenyl isothiocyanate

Sigma Grade, 8.36 M, suitable for solid phase protein sequencing analysis, ≥99% (GC), liquid

• Synonyma: PITC
• Lineární vzorec: C₆H₅NCS
• Číslo CAS: 103-72-0
• Molekulová hmotnost: 135.19
• Beilstein/REAXYS Number: 471392
• EC Number: 203-138-1
• MDL number: MFCD00004798
• UNSPSC Code: 12352118
• PubChem Substance ID: 24898144
• NACRES: NA.31

Vlastnosti

• grade: Sigma Grade
• Quality Level: 100
• assay: ≥99% (GC)
• form: liquid
• concentration: 8.36 M
• refractive index: n20/D 1.6515 (lit.)
• bp: 218 °C (lit.)
• mp: −21 °C (lit.)
• density: 1.132 g/mL at 20 °C (lit.)
• suitability: suitable for solid phase protein sequencing analysis
• storage temp.: 2-8°C
• SMILES string: S=C=Nc1ccccc1
• InChI: 1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H
• InChI key: QKFJKGMPGYROCL-UHFFFAOYSA-N

Popis

General description

Phenyl isothiocyanate belongs to the class of aromatic compounds with isothiocyanate groups. It is typically used as a precolumn derivatization agent for the formation of phenylthiocarbamyl amino acids for their subsequent determination using chromatography techniques.

Application

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

Phenyl isothiocyanate may be used in the polypeptide and protein sequencing at the subpicomole and subnanomole levels, respectively, by applying automated Edman chemistry followed by the analysis using high-performance liquid chromatography (HPLC) technique.

Packaging

One mL size packaged in flame sealed amber ampules under argon.
Ten mL size packaged in screw cap amber vials under argon.

Bezpečnostní informace

• pictograms: GHS06,GHS08,GHS05
• signalword: Danger
• hcodes: H301,H314,H317,H334
• pcodes: P261 - P272 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 190.4 °F - closed cup
• flash_point_c: 88 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter