N7537

NSC 663284

≥98% (HPLC), solid

• Synonyma: 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Empirický vzorec (Hillův zápis): C₁₅H₁₆ClN₃O₃
• Číslo CAS: 383907-43-5
• Molekulová hmotnost: 321.76
• MDL number: MFCD08276924
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724556
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: red
• solubility: DMSO: ≥10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChI key: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Gene Information: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Popis

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 470.1 °F
• flash_point_c: 243.4 °C
• ppe: dust mask type N95 (US), Eyeshields, Gloves