Přejít k obsahu
Merck
Všechny fotografie(3)

Hlavní dokumenty

Zobrazit celou dokumentaci

M5644

Sigma-Aldrich

(±)-Methoxyverapamil hydrochloride

≥98%

Synonyma:

(±)-α-[3-[(2-(3,4-Dimethoxyphenyl)ethyl)methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride, D 600, Gallopamil

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Všechny fotografie(3)

About This Item

Empirický vzorec (Hillův zápis):
C28H40N2O5 · HCl
Číslo CAS:
16662-47-8
Molekulová hmotnost:
521.09
MDL number:
MFCD00058000
UNSPSC Code:
12352200
PubChem Substance ID:
24277852
NACRES:
NA.77

Quality Level

200

assay

≥98%

SMILES string

Cl[H].COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC

InChI

1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5;/h10-11,16-18,20H,9,12-15H2,1-8H3;1H

InChI key

OKCRIUNHEQSXFD-UHFFFAOYSA-N

Hledáte podobné produkty? Navštivte Průvodce porovnáváním produktů

Související kategorie

General description

Methoxyverapamil is a calmodulin antagonist. It controls flagellar glycoprotein redistribution by modulating calcium signalling. Methoxyverapamil impacts the effect of intracellular calcium levels and affects the sperm capacitation function.

Application

(±)-Methoxyverapamil hydrochloride has been used:
  • as calcium channel antagonist in Schistosoma mansoni parasite
  • as calcium entry blocker in cultured macrophages
  • in the inhibition of L-type voltage gated Ca2+-channels

Biochem/physiol Actions

Blocks L-type Ca2+ channels

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number
038F0122

Nevidíte správnou verzi?

Potřebujete-li konkrétní verzi, můžete vyhledat daný certifikát podle čísla dávky nebo čísla šarže.

Vyhledat COA

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Zákazníci si také prohlíželi

Slide 1 of 7

1 of 7

Verapamil hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-002

Verapamil hydrochloride solution

(±)-Verapamil hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1131

(±)-Verapamil hydrochloride

(+)-cis-Diltiazem hydrochloride ≥99% (HPLC)

Sigma-Aldrich

D2521

(+)-cis-Diltiazem hydrochloride

Carbachol European Pharmacopoeia (EP) Reference Standard

Y0000113

Carbachol

Nifedipine ≥98% (HPLC), powder

Sigma-Aldrich

N7634

Nifedipine

(±)-Propranolol hydrochloride ≥99% (TLC), powder

Sigma-Aldrich

P0884

(±)-Propranolol hydrochloride

Thapsigargin ≥98% (HPLC), solid film

Sigma-Aldrich

T9033

Thapsigargin

Iliyana D Stefanova et al.
Molecular nutrition & food research, 51(4), 468-472 (2007-03-16)
Melanoidins obtained from L-arginine and D-glucose (MW > 3500 Da) were tested for their ability to influence the contractility of gastric smooth muscles. A study within the range 0.1-10 mg/mL revealed that at low concentrations, the melanoidins provoked concentration-dependent contraction
D N Serban et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 108(2), 445-451 (2005-02-04)
Membrane potential (MP) is essential in smooth muscle (SM) contractile activity, mainly by its effect upon L-type Ca2+ channels. We simultaneously recorded SM isometric tension and MP in de-endothelised rat aorta rings and examined their submaximal activation by K+, norepinephrine
Shigehiro Hayashi et al.
Acta pharmacologica Sinica, 31(1), 19-26 (2009-11-17)
To quantitatively assess the effect of lowering external Ca(2+) ([Ca(2+)](o)) on both endothelium-dependent and -independent relaxations in rabbit aorta. Isometric contractions and relaxations of isolated aortae were recorded. When assessing the effect of reduced [Ca(2+)](o) on relaxations, the normal [Ca(2+)](o)
Anamika Awasthi et al.
Bioorganic & medicinal chemistry letters, 15(24), 5412-5415 (2005-10-11)
Ab initio Hartree-Fock calculations have been performed at the 6-31G level to study the pharmacophoric features of verapamil. Both the unprotonated and the protonated forms of verapamil have been studied. The study predicts that the drug enters the body in
Beatrice Pöschel et al.
Neuropharmacology, 52(1), 46-54 (2006-08-11)
Hippocampal long-term depression (LTD) comprises a persistent reduction of synaptic strength that is typically induced by low frequency stimulation (LFS). Although LTD has been described for the dentate gyrus in vitro, this phenomenon in the dentate gyrus of the intact
Zobrazit všechny související dokumenty

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.