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M5319

Sigma-Aldrich

Matrine

Synonyma:

Matridin-15-one, Sophocarpidine

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

Empirický vzorec (Hillův zápis):
C15H24N2O
Číslo CAS:
519-02-8
Molekulová hmotnost:
248.36
MDL number:
MFCD00210527
UNSPSC Code:
12352200
PubChem Substance ID:
329818010
NACRES:
NA.25

Quality Level

100

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O=C1CCCC2C3CCCN4CCCC(CN12)C34

InChI

1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1

InChI key

ZSBXGIUJOOQZMP-JLNYLFASSA-N

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General description

Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.

Application

Matrine has been used:
  • to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells
  • as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells, and ovarian cancer cells
  • to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells
  • as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines

Biochem/physiol Actions

Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties. It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level. Matrine may also serve as an effective sedative agent. It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice. It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.
Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Hyun-Ju Lee et al.
Biomolecules & therapeutics, 25(4), 390-395 (2017-02-14)
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by
Can Hu et al.
Acta pharmaceutica Sinica. B, 9(4), 690-701 (2019-08-07)
Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and try to
Beibei Xu et al.
Cell death discovery, 3, 16096-16096 (2017-02-10)
The development of acquired resistance to pro-apoptotic antitumor agents is a major impediment to the cure of cholangiocarcinoma (CCA). Antitumor drugs inducing non-apoptotic cell death are considered as a new approach to overcome such drug resistance. Here, we reported for
Longtai You et al.
Frontiers in pharmacology, 11, 01067-01067 (2020-10-13)
Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective
Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.
Zhang Y, Dong Z, Jin L, et al.
Biochemical Pharmacology (2012)
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