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E2250

Ellagic acid

Name: Ellagic acid
Brand: SIGMA
Price: 3950 CZK

≥95% (HPLC), powder, from tree bark

Synonyma:

4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Eleagic acid, Gallogen, Lagistase

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Velikost balení	Dostupnost	Cena
1 g	Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	3 950,00 Kč
5 g	Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	12 700,00 Kč
10 g	Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.	24 400,00 Kč

O této položce

Empirický vzorec (Hillův zápis):

C₁₄H₆O₈

Číslo CAS:

476-66-4

Molekulová hmotnost:

302.19

UNSPSC Code:

12352205

NACRES:

NA.77

PubChem Substance ID:

24894460

EC Number:

207-508-3

Beilstein/REAXYS Number:

47549

MDL number:

MFCD00006914

3 950,00 Kč

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Vlastnosti

biological source

tree bark

Quality Segment

200

assay

≥95% (HPLC)

form

powder

shelf life

5 yr

solubility

1 M NaOH: 10 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

Oc1cc2C(=O)Oc3c(O)c(O)cc4C(=O)Oc(c1O)c2-c34

InChI

1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

InChI key

AFSDNFLWKVMVRB-UHFFFAOYSA-N

Gene Information

human ... CSK(1445), DYRK1A(1859), GSK3B(2932), SRC(6714)
rat ... Lyn(81515), Syk(25155)

Popis

General description

Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite. It is commonly found in green tea, pomegranate, strawberries, blackberries, raspberries, and walnuts.[1]

Application

Ellagic acid has been used:

to study the metabolism of dietary phenolic acids by Lactobacillus plantarum CECT 748T
as a potential substrate for the high production of Lactobacillus plantarum tannase[2]
as a standard in the study to examine the phenolic components and anti-oxidant activity of nettle[3]
to study the links between dietary ellagic acid and epigenetic modulation of adipogenesis[4]

Biochem/physiol Actions

Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.

Ellagic acid has been found to exhibit antioxidant activity by virtue of having an inhibitory effect on the oxidation of low-density lipoproteins. This makes them have a cardioprotective effect on humans. In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well.[1]

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Tato položka	14668	PHL89653	91904
Sigma-Aldrich E2250 Ellagic acid	Supelco 14668 Ellagic acid	PHL89653 Ellagic acid	Supelco 91904 Violaxanthin
form powder	form -	form powder	form -
assay ≥95% (HPLC)	assay ≥95.0% (HPLC)	assay ≥98.0% (HPLC)	assay ≥95.0% (HPLC)
biological source tree bark	biological source -	biological source -	biological source -
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 100
application(s) metabolomics vitamins, nutraceuticals, and natural products	application(s) food and beverages	application(s) -	application(s) cleaning products cosmetics food and beverages personal care
solubility 1 M NaOH: 10 mg/mL	solubility -	solubility -	solubility -

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Skladovací třída

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Osvědčení o analýze (COA)

Lot/Batch Number

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Sortimentní položky

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Detecting oral kallikrein-targeting therapy through triggered contact activation: A phase I study.

Zonne L M Hofman et al.

The Journal of allergy and clinical immunology, 146(6), 1446-1449 (2020-05-04)

Metabolism of food phenolic acids by Lactobacillus plantarum CECT 748T

Rodriguez H, et al.

Food Chemistry, 107(4), 1393-1398 (2008)

Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification.

Inhae Kang et al.

The Journal of nutritional biochemistry, 25(9), 946-953 (2014-06-16)

Chromatin remodeling is a key mechanism in adipocyte differentiation. However, it is unknown whether dietary polyphenols are epigenetic effectors for adiposity control. Ellagic acid (EA) is a naturally occurring polyphenol in numerous fruits and vegetables. Recently, EA-containing foods have been

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Globální číslo obchodní položky

Skladová položka	GTIN
E2250-5G	04061835512478
E2250-10G	04061833602539
E2250-1G	04061835516001

Questions

1–3 of 3 Questions

Anonymous

10 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  10 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

2 years ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  2 years ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?
3 years ago

as per your data ellagic acid solubility is 10mg/mL in 1M NaOH, but is it stable in this diluent??

1 answer
1. Technical Support
  
  2 years ago
  
  The stability of this product in solution is not determined.
  Please see the link below to review a publication that may be helpful:
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645270/
  
  Helpful?

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