D7071

Dapoxetine hydrochloride

≥98% (HPLC)

• Synonyma: (S)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride, S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride
• Empirický vzorec (Hillův zápis): C₂₁H₂₃NO · HCl
• Číslo CAS: 129938-20-1
• Molekulová hmotnost: 341.87
• MDL number: MFCD08272809
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798842
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +125 to +135°, c = 1 in methanol
• storage condition: desiccated
• color: white
• solubility: DMSO: ≥20 mg/mL
• originator: Eli Lilly
• storage temp.: room temp
• SMILES string: Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3
• InChI: 1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1
• InChI key: IHWDIQRWYNMKFM-BDQAORGHSA-N
• Gene Information: human ... SLC6A4(6532)

Popis

General description

Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.

Biochem/physiol Actions

Dapoxetine is capable of blocking recombinant Kv4.3 potassium voltage-gated channels. It is considered as safe.

Potent Selective serotonin reuptake inhibitor (SSRI); used in treatment of premature ejaculation

Potent and selective SSRI

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319,H413
• pcodes: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable