C8742

CHIC-35

≥97% (chiral, HPLC)

• Synonyma: (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35
• Empirický vzorec (Hillův zápis): C₁₄H₁₅ClN₂O
• Číslo CAS: 848193-72-6
• Molekulová hmotnost: 262.73
• MDL number: MFCD11045286
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775186
• NACRES: NA.77

Vlastnosti

• assay: ≥97% (chiral, HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
• InChI: 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
• InChI key: ABIVOOWWGYJNLV-JTQLQIEISA-N

Popis

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC₅₀ of S-isomer is 60 nM; IC₅₀ of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC₅₀ for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves