Přejít k obsahu
Merck
Všechny fotografie(1)

Hlavní dokumenty

Zobrazit celou dokumentaci

Y0000049

Amlodipine besylate

European Pharmacopoeia (EP) Reference Standard

Synonyma:

2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Všechny fotografie(1)

About This Item

Empirický vzorec (Hillův zápis):
C20H25ClN2O5 · C6H5SO3H
Číslo CAS:
111470-99-6
Molekulová hmotnost:
567.05
MDL number:
MFCD00887594
UNSPSC Code:
41116107
PubChem Substance ID:
329830828
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

amlodipine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC

InChI

1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

InChI key

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Hledáte podobné produkty? Navštivte Průvodce porovnáváním produktů

Související kategorie

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amlodipine besylate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Amlodipine besylate is an L-type calcium channel blocker.
Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Č. produktu
Popis
Stanovení ceny

1029501

Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard

Y0001068

Amlodipine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001069

Amlodipine impurity B, European Pharmacopoeia (EP) Reference Standard

Y0001070

Amlodipine impurity G, European Pharmacopoeia (EP) Reference Standard

Y0001067

Amlodipine for peak identification, European Pharmacopoeia (EP) Reference Standard

1029512

Amlodipine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1029545

Amlodipine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1029534

Amlodipine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1029614

Amlodipine Related Compound K, United States Pharmacopeia (USP) Reference Standard

59872

2-[[2-[(2-Carboxybenzoyl)amino]ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester, reference material

51818

Diethyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, reference material

PHR2050

Amlodipine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2052

Amlodipine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2051

Amlodipine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2053

Amlodipine Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2056

Amlodipine Related Compound K, Pharmaceutical Secondary Standard; Certified Reference Material

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumenty section.

Potřebujete-li pomoc, obraťte se na Zákaznická podpora

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Zákazníci si také prohlíželi

Slide 1 of 8

1 of 8

Telmisartan European Pharmacopoeia (EP) Reference Standard

Y0000648

Telmisartan

USP

USP

1029512

Amlodipine Related Compound A

Olmesartan Medoxomil Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1851

Olmesartan Medoxomil

USP

USP

1098027

Cefpodoxime proxetil

Valsartan European Pharmacopoeia (EP) Reference Standard

Y0001132

Valsartan

Amlodipine Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2050

Amlodipine Related Compound A

Valsartan United States Pharmacopeia (USP) Reference Standard

USP

1708762

Valsartan

S-(5′-Adenosyl)-L-homocysteine crystalline

Sigma-Aldrich

A9384

S-(5′-Adenosyl)-L-homocysteine

Juliano Lara Fernandes et al.
The American journal of medicine, 126(9), 834-837 (2013-07-09)
Iron chelation therapy in patients with thalassemia major may not prevent iron overload in all organs, especially those in which iron enters cells through specific calcium channels. We designed a controlled pilot study to assess the potential of the calcium
S Neldam et al.
International journal of clinical practice, 67(9), 843-852 (2013-08-21)
Rapid and sustained blood pressure (BP) goal attainment is important to reduce cardiovascular risk. Initial use of combination therapy may improve BP goal attainment. The Boehringer Ingelheim trial database was searched for randomised, double-blind studies comparing telmisartan/amlodipine combination therapy with
Christopher J Cooper et al.
The New England journal of medicine, 370(1), 13-22 (2013-11-20)
Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the usefulness of stenting for the prevention of major adverse renal and
Keiichiro Mishima et al.
American journal of physiology. Renal physiology, 304(6), F665-F673 (2013-01-18)
N-type Ca(2+) channels are densely distributed in sympathetic nerves that innervate renal tubules. However, the role of N-type Ca(2+) channels in renal fibrosis remains unknown. To address this issue, we examined the difference between the effects of amlodipine (an L-type
Rishi Puri et al.
Journal of the American College of Cardiology, 65(13), 1273-1282 (2015-04-04)
Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. This study compared changes in coronary atheroma volume and calcium indices
Zobrazit všechny související dokumenty

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.