SMB01363

5α-Tetrahydrocortisol

≥95% (HPLC)

• Synonyma: 5α-Pregnane-3α,11β,17α,21-tetrol-20-one, α-THF, 5 alpha-Tetrahydrocortisol, ATHF, Allo-3a-tetrahydrocortisol, 3α,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one, 3α,5α-Tetrahydrocortisol, Allopregnane-3α,11β,17α,21-tetrol-20-one, Allotetrahydrocortisol, Kendall’s compound C, Reichstein’s substance C
• Empirický vzorec (Hillův zápis): C₂₁H₃₄O₅
• Číslo CAS: 302-91-0
• Molekulová hmotnost: 366.49
• MDL number: MFCD00003670
• UNSPSC Code: 51111800
• NACRES: NA.21

Vlastnosti

• Quality Level: 200
• assay: ≥95% (HPLC)
• form: solid
• composition: (3α,5α)-3,11,17,21-Tetrahydroxypregnan-20-one, ≤100%
• packaging: pkg of 25 mg; pkg of 5 mg
• color: white to beige
• mp: 244.5 °C
• density: 1.205 g/cm³
• storage temp.: 2-8°C
• SMILES string: C[C@@]12CC[C@H](O)C[C@H]1CC[C@@H]3[C@H]4CC[C@@](O)(C(=O)CO)[C@@]4(C)C[C@@H](O)[C@@H]23
• InChI: 1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-16,18,22-24,26H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: AODPIQQILQLWGS-FDSHTENPSA-N

Popis

General description

5α-Tetrahydrocortisol, also known as Allo-3a-tetrahydro cortisol (ATHC), a synthetic corticosteroid hormone derived from cortisol, is widely employed in biochemical and proteomics research. It is a metabolite of cortisol, a natural glucocorticoid that is used to treat various immune, inflammatory, and neoplastic conditions. In the context of medical diagnosis, a higher ratio of specific urinary metabolites can indicate the presence of Apparent Mineralocorticoid Excess (AME) syndrome, a rare form of hypertension linked to abnormalities in cortisol metabolism.

Application

5α-Tetrahydrocortisol finds application as a Biomarker in AME studies pertaining to Cortisol metabolism research

Features and Benefits

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Other Notes

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Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H317,H413
• pcodes: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Hazard Classifications: Aquatic Chronic 4 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable