PHR1161

Procaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyma: 4-Aminobenzoic acid 2-diethylaminoethyl ester, p-Aminobenzoic acid diethylaminoethyl ester hydrochloride, Novocaine hydrochloride
• Lineární vzorec: H₂NC₆H₄CO₂CH₂CH₂N(C₂H₅)₂·HCl
• Číslo CAS: 51-05-8
• Molekulová hmotnost: 272.77
• Beilstein/REAXYS Number: 3917802
• EC Number: 200-077-2
• MDL number: MFCD00013000
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823178
• NACRES: NA.24

Vlastnosti

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1564006
• API family: procaine
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 155-156 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1
• InChI: 1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
• Inchi Key: HCBIBCJNVBAKAB-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Popis

General description

Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Procaine hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrochemical, chemiluminescence, and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7177 in the slot below. This is an example certificate only and may not be the lot that you receive.

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H317
• pcodes: P261 - P264 - P270 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Skin Sens. 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable