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Key Documents

MAB80121

Sigma-Aldrich

Anti-Human Metapneumovirus Antibody, clone 36

clone 36, Chemicon®, from mouse

Synonyma:

hMPV

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.42

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

36, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable

isotype

IgG2a

shipped in

wet ice

Související kategorie

General description

Human metapneumovirus (hMPV) is a member of the pneumovirinae subfamily of paramyxoviruses, first described in 2001 from pediatric respiratory specimens in the Netherlands. It is an enveloped pleomorphic virus with a single negative-strand RNA genome. Two major serotypes, A and B, have been described. Several studies identified hMPV in specimens worldwide, and estimated that by age 5 years 70% of children have developed antibodies to hMPV.

Specificity

Specific to the nuclear protein. Reactive with all sub-types; A1, A2, B1, B2.

Application

Detect Human Metapneumovirus using this Anti-Human Metapneumovirus Antibody, clone 36 validated for use in ELISA, FC & IF.
Research Category
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral

Physical form

Format: Purified
Liquid in 0.02M PB with 0.25M NaCl, pH 7.6. Contains 0.1% sodium azide.

Storage and Stability

Store at 2° to 8°C for up to 12 months from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Kathleen M Nitschinsk et al.
Intervirology, 61(3), 149-154 (2018-08-27)
Human metapneumovirus (hMPV) is an important human respiratory pathogen and is implicated in an array of respiratory illnesses, ranging from asymptomatic infection to severe bronchiolitis. Currently, there is no reliable vaccine or specific antiviral therapy for hMPV infection and treatment
Fernando Villalón-Letelier et al.
mBio, 12(5), e0148421-e0148421 (2021-09-15)
Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reducing their incorporation into virions. Using stable cell lines with inducible MARCH8 expression, we show that MARCH8 did not alter susceptibility to influenza A virus (IAV)
Leah Gillespie et al.
Journal of virology, 90(17), 7848-7863 (2016-06-24)
It is well established that glycosaminoglycans (GAGs) function as attachment factors for human metapneumovirus (HMPV), concentrating virions at the cell surface to promote interaction with other receptors for virus entry and infection. There is increasing evidence to suggest that multiple
Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy.
Maggi, Fabrizio, et al.
Journal of Clinical Microbiology, 41, 2987-2991 (2003)

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