AB15080

Anti-Frataxin Antibody

from rabbit

• Synonyma: Anti-CyaY, Anti-FA, Anti-FARR, Anti-FRDA, Anti-X25
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Vlastnosti

• biological source: rabbit
• Quality Level: 100
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: rat, mouse, human
• technique(s): western blot: suitable
• NCBI accession no.: NP_000135
• UniProt accession no.: Q16595
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... FXN(2395) ; mouse ... Fxn(14297) ; rat ... Fxn(499335)

Popis

General description

Frataxin is a nuclear encoded protein that is found in the mitochondria. This protein is not well understood but may be involved with iron sulfur clusters. In humans the gene is localized on chromosome 9 and is highly conserved during evolution. The gene is expressed in every cell, although in varying levels in different tissues and during development. The specific function of Frataxin is still unknown, but it has been shown to play a role in iron metabolism. Studies have demonstrated that the deletion of the Frataxin gene in yeast results in iron accumulation in mitochondria and loss of respiration. Recombinant human Frataxin has been shown to bind iron in vitro, and increased mitochondrial iron levels have been observed in patients with Friedreich′s Ataxia (FRDA).

Specificity

Cat. # AB15080 recognizes Frataxin.

Immunogen

Epitope: mature chain

GST-tagged Frataxin corresponding to mature chain.

Application

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This Anti-Frataxin Antibody is validated for use in WB for the detection of Frataxin.

Quality

Routinely evaluated by Western Blot on Human heart lysates.

Western Blot Analysis: 1:1,000 - 1:10,000 dilution of this lot detected Frataxin on 10 ug of human heart lysate

Target description

Approx. 18 kDa

Physical form

Format: Purified

GST-depleted sera

Rabbit polyclonal serum in buffer containing 0.05% NaN3.

Storage and Stability

Stable for 1 year at -20ºC from date of receipt.

Analysis Note

Control
Human heart lysate.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Bezpečnostní informace

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable