4995

Ouabain octahydrate

≥95% (HPLC), solid, Na⁺,K⁺-ATPase inhibitor, Calbiochem^®

• Synonyma: Ouabain, Octahydrate, Strophanthin G
• Empirický vzorec (Hillův zápis): C₂₉H₄₄O₁₂ · 8H₂O
• Číslo CAS: 11018-89-6
• Molekulová hmotnost: 728.77
• MDL number: MFCD00149240
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Název produktu: Ouabain, Octahydrate, Inhibits Na⁺,K⁺-ATPase.
• Quality Level: 100
• description: RTECS - RN3850000; Merck USA index - 14 6901
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to off-white
• solubility: hot water: 10 mg/mL; room-temperature water: insoluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O1CC(=CC1=O)[C@@H]2C3(C(C4[C@H]([C@@H](C3)O)C5([C@@H](C[C@@H](CC5(CC4)O)OC6OC(C(C(C6O)O)O)C)O)CO)(CC2)O)C.O.O.O.O.O.O.O.O
• InChI: 1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13?,15-,16+,17?,18+,19+,21+,22?,23?,24?,25?,26?,27?,28?,29?;;;;;;;;/m0......../s1
• InChI key: TYBARJRCFHUHSN-HMNHGHQSSA-N

Popis

General description

Inhibits Na⁺ and K⁺-dependent ATPases. Has cardiotonic properties.

Inhibits Na⁺,K⁺-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G₂ delay.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.
Xu, Z.J., et al. 1992. J. Physiol.456, 405.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H331,H373
• pcodes: P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3