344101

FSB

A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.

• Synonyma: FSB, (E,E)-1-Fluoro-2,5- bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
• Empirický vzorec (Hillův zápis): C₂₄H₁₇FO₆
• Číslo CAS: 760988-03-2
• Molekulová hmotnost: 420.39
• MDL number: MFCD28902305
• UNSPSC Code: 41105331
• NACRES: NA.25

Vlastnosti

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Fc1c(ccc(c1)\C=C\c3cc(c(cc3)O)C(=O)O)\C=C\c2cc(c(cc2)O)C(=O)O
• InChI key: DZXZHGCGNRRJEG-WMWQKROPSA-N

Popis

General description

A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients with improved sensitivity, and reduced background.

This fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI. Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients, with improved sensitivity and reduced background.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Amyloidophilic fluorescent probe

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Higuchi, M., et al. 2005. Nat. Neurosci.8, 527.
Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable