341310

FABP4 Inhibitor

The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

• Synonyma: FABP4 Inhibitor, adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
• Empirický vzorec (Hillův zápis): C₃₁H₂₆N₂O₃
• Číslo CAS: 300657-03-8
• Molekulová hmotnost: 474.55
• MDL number: MFCD09991687
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 200
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: ethanol: 20 mg/mL; DMSO: 50 mg/mL; methanol: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [n]3(nc(c(c3CC)c5ccccc5)c4ccccc4)c1c(cccc1)c2cc(ccc2)OCC(=O)O
• InChI: 1S/C31H26N2O3/c1-2-27-30(22-12-5-3-6-13-22)31(23-14-7-4-8-15-23)32-33(27)28-19-10-9-18-26(28)24-16-11-17-25(20-24)36-21-29(34)35/h3-20H,2,21H2,1H3,(H,34,35)
• InChI key: SJRVJRYZAQYCEE-UHFFFAOYSA-N

Popis

General description

A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (K_i = <2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP′s (K_i = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Furuhashi, M., et al. 2007. Nature447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable