309866

Diltiazem, Hydrochloride

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist.

• Synonyma: Diltiazem, Hydrochloride, L-Type Calcium Channel Blocker II
• Empirický vzorec (Hillův zápis): C₂₂H₂₆N₂O₄S · xHCl
• Číslo CAS: 33286-22-5
• Molekulová hmotnost: 414.52 (free base basis)
• MDL number: MFCD00069252
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• description: Merck USA index - 14, 3202
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 50 mg/mL; chloroform: soluble; methanol: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: S1[C@H]([C@H](C(=O)N(c3c1cccc3)CC[N+H](C)C)OC(=O)C)c2ccc(cc2)OC.[Cl-]
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• InChI key: HDRXZJPWHTXQRI-BHDTVMLSSA-N

Popis

General description

Synthetic (+)-cis isomer that acts as an L-type Ca²⁺ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Biochem/physiol Actions

Cell permeable: no

Primary Target
L-type Ca2+ channel

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Other Notes

van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable