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Merck
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Key Documents

06-867

Sigma-Aldrich

Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody

serum, Upstate®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_003152.2

UniProt accession no.

P42229

shipped in

dry ice

target post-translational modification

phosphorylation (pSer726)

Gene Information

human ... STAT5A(6776)

Specificity

phosphorylated STAT5A (S726) and STAT5B (S731), does not recognize STAT5B containing a S731A mutation

Immunogen

peptide (DQAP[pS]PAVC) corresponding to amino acids 722-730 of human STAT5A or 727-735 of human STAT5B

Application

Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody is a rabbit polyclonal antibody for detection of phospho-STAT5A/B (Ser726/Ser731) also known as signal transducer & activator of transcription 5A/B & has been tested in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

routinely evaluated by immunoprecipitating STAT5A from RIPA lysates of Nb2-Sp cells that had been treated with prolactin; subsequent immunoblotting was performed using Anti-STAT5A (Catalog #06-968)

Target description

94kDa

Physical form

Antiserum
rabbit antiserum in 30% glycerol and 0.05% sodium azide

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Development of pure prolactin receptor antagonists.
Bernichtein, S; Kayser, C; Dillner, K; Moulin, S; Kopchick, JJ; Martial, JA; Norstedt et al.
The Journal of Biological Chemistry null
P L Bergad et al.
The Journal of biological chemistry, 275(11), 8114-8120 (2000-03-14)
A growth hormone-inducible nuclear factor complex (GHINF), affinity-purified using the growth hormone response element (GHRE) from the promoter of rat serine protease inhibitor 2.1, was found to contain Stat5a and -5b, as well as additional components. The ubiquitous transcription factor
H Yamashita et al.
The Journal of biological chemistry, 273(46), 30218-30224 (1998-11-07)
Transcription factors of the Stat family are controlled by protein kinases. Phosphorylation of a positionally conserved tyrosine residue is obligatory for Stat dimerization, nuclear translocation, and specific DNA binding. Studies of Stat1 and Stat3 have suggested that serine phosphorylation may
R A Kirken et al.
The Journal of biological chemistry, 272(22), 14098-14103 (1997-05-30)
Transcription factors of the Stat gene family are selectively activated by many hormones and cytokines. Stat5 originally was cloned as a prolactin-stimulated DNA-binding protein, but is also activated by non-lactogenic cytokines in many cell types. The recent identification of two
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Kirken, R A, et al.
The Journal of Biological Chemistry, 272, 15459-15465 (1997)

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