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810219P

Avanti

C12-NBD Sphingomyelin

Avanti Research™ - A Croda Brand 810219P, powder

Synonyma:

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sphingosine-1-phosphocholine

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About This Item

Empirický vzorec (Hillův zápis):
C41H73N6O9P
Číslo CAS:
254117-01-6
Molekulová hmotnost:
825.03
MDL number:
MFCD02259246
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810219P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810219P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](NC(=O)CCCCCCCCCCCNc1c2n[o]nc2c(cc1)[N+](=O)[O-])[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C41H73N6O9P/c1-5-6-7-8-9-10-11-12-13-15-18-21-24-27-38(48)36(34-55-57(52,53)54-33-32-47(2,3)4)43-39(49)28-25-22-19-16-14-17-20-23-26-31-42-35-29-30-37(46(50)51)41-40(35)44-56-45-41/h24,27,29-30,36,38,48H,5-23,25-26,28,31-34H2,1-4H3,(H2-,42,43,45,49,52,

InChI key

FCQMKLRMKNYONQ-YPGNEAGUSA-N

General description

C12-NBD Sphingomyelin is a fluorescent analog of biologically active molecule, sphingomyelin. Sphingomyelin is predominantly found in the animal plasma membrane. It is abundantly present as component of cell membranes in mammals, nematodes, protozoa.

application

C12-NBD-sphingomyelin has been used as a substrate to test substrate specificity of neutral ceramidase orthologue encoded by AsahA gene.

Biochem/physiol Actions

Sphingomyelin (SM) is produced from phosphatidylcholine and ceramide on the cell surface and in lumen of the Golgi. SM′s high packing density and affinity to sterols form a rigid barrier to the extracellular environment. SM is also involved in the formation of lipid rafts in cell membranes, which perform important functions in signal transduction and membrane trafficking.

Packaging

5 mL Amber Glass Screw Cap Vial (810219P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can

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