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923958

Sigma-Aldrich

6F,C5-Pomalidomide-4-piperidine-C1-piperazine hydrochloride

Synonyma:

2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(piperazin-1-ylmethyl)piperidin-1-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block

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About This Item

Empirický vzorec (Hillův zápis):
C23H28FN5O4 · xHCl
Molekulová hmotnost:
457.50 (free base basis)
MDL number:
MFCD34602213
UNSPSC Code:
12352200
NACRES:
NA.21

ligand

6F,C5-Pomalidomide

Quality Level

100

reaction suitability

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

functional group

amine

storage temp.

2-8°C

SMILES string

O=C1C(N2C(C(C=C(F)C(N(CC3)CCC3CN4CCNCC4)=C5)=C5C2=O)=O)CCC(N1)=O.Cl

InChI key

NSESLQMRUIXJGI-UHFFFAOYSA-N

Související kategorie

Application

Protein degrader building block 6F,C5-Pomalidomide-4-piperidine-C1-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Č. produktu
Popis
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Pomalidomide-piperazine-pyridine-alkyne-NH2 hydrochloride

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C5 Lenalidomide-piperazine-pyridine-alkyne-NH2 hydrochloride, ≥95%

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(S,R,S)-AHPC-PEG1-piperazine hydrochloride, ≥95%

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(S,R,S)-AHPC-alkyne-piperidine hydrochloride

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C5 Lenalidomide-benzyl-piperazine hydrochloride

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Pomalidomide-pyridine-PEG1-piperazine hydrochloride

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C5 Lenalidomide-pyridine-PEG1-piperazine hydrochloride, ≥95%

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C5 Lenalidomide-methylamino-PEG1-NH2 hydrochloride, ≥95%

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(S,R,S)-VL285 Phenol-PEG1-piperazine hydrochloride

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(S,R,S)-AHPC-methylamino-PEG1-NH2 hydrochloride

921300

C5 Lenalidomide-pyrimidine-piperazine-PEG1-NH2 hydrochloride, ≥95%

921319

Pomalidomide-methylamino-PEG1-NH2 hydrochloride

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(S,R,S)-AHPC-pyridine-PEG1-piperazine hydrochloride

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(S,R,S)-VL285 Phenol-C3-piperazine hydrochloride

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(S,R,S)-AHPC-pyrimidine-piperazine-PEG1-NH2 hydrochloride

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number
0000140624
0000134264

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