923389

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid

• Synonyma: Rigid linker for PROTAC^® development
• Empirický vzorec (Hillův zápis): C₁₈H₃₀N₂O₅
• Molekulová hmotnost: 354.44
• MDL number: MFCD34602206
• UNSPSC Code: 12352106
• NACRES: NA.22

Vlastnosti

• form: powder or crystals
• Quality Level: 100
• reaction suitability: reagent type: linker
• functional group: Boc; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: O=C(O)C(CC1)CCN1CC(CC2)OC32CN(C(OC(C)(C)C)=O)C3
• InChI key: CVHPZSHLWZEYQS-UHFFFAOYSA-N

Popis

Application

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Other Notes

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable