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763918

Sigma-Aldrich

DL-α-Tocopherol methoxypolyethylene glycol succinate solution

greener alternative

5 wt. % in H2O

Synonyma:

Polyethylene glycol, TPGS-750-M

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About This Item

Lineární vzorec:
(C2H4O)nC34H56O5
Číslo CAS:
1309573-60-1
UNSPSC Code:
51171641
NACRES:
NA.22

form

liquid

Quality Level

100

reaction suitability

reagent type: catalyst
reaction type: C-H Activation
reagent type: surfactant

IVD

for in vitro diagnostic use

greener alternative product characteristics

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

concentration

5 wt. % in H2O

refractive index

n20/D 1.340

density

0.981 g/mL at 25 °C

greener alternative category

Aligned,

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General description

Learn More at the Professor and Product Portal of Professor Bruce Lipshutz.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product TPGS-750-M is a lead surfactant for many transition metal-catalyzed cross-couplings and has been enhanced for catalytic efficiency. Find details here.

Application

On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors
Nonionic amphile used to increase aqueous solubility of lipophilic catalysts and substrates. Olefin metathesis, Sonogashira, Suzuki-Miyaura, and Buchwald cross-coupling reactions have been successfully performed in aqueous media employing TPGS-750-M.
Second generation amphiphile which forms micelles upon dissolution in water allowing a variety of cross-coupling reactions to take place in water instead of organic solvent.

Included among the possible reactions are:
  • Olefin metathesis
  • Pd-catalyzed cross coupling reactions including Heck, Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig reactions
  • C-H activation reactions

Second generation amphiphile for cross-coupling reactions in water

Other Notes

Watch Professor Lipshutz talk about TPGS-750-M in this webinar:
From milligrams to kilograms: synthetic chemistry following nature′s lead

Related product

Č. produktu
Popis
Stanovení ceny

902292

EvanPhos, ≥95%

907014

Coolade

909793

Coolade solution, 2 wt. % in H2O

911151

PS-750-M

911178

PS-750-M, solution, 3 wt. % in H2O

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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TERGITOL™ Type 15-S-9

Sigma-Aldrich

15S9

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Sortimentní položky

TPGS-750-M: Second-Generation Amphiphile for Organometallic Chemistry in Water at Room Temperature

Lipshutz and co-workers have recently developed a second generation technology to their original PTS-enabling surfactant based on the polyoxyethanyl-α-tocopheryl succinate derivative, TPGS-750-M.

Lipshutz Surfactants Portfolio

Surfactants for efficient reactions in water as a green chemistry alternative.

Palladium-catalyzed Cross-coupling Reactions

A variety of palladium-catalyzed cross-coupling reactions can be run under room temperature conditions in water with TPGS- 750-M, using a variety of commercially available palladium complexes and ligands.

Protokoly

Cross-Coupling Reactions in Water

TPGS-750-M surfactant enables various reactions in water at room temperature, enhancing efficiency and versatility in synthesis.

Související obsah

Lipshutz Group – Professor Product Portal

Prof. Bruce Lipshutz and co-workers have developed designer surfactants to allow several classes of transformations (e.g. Suzuki-Miyaura, Olefin Metathesis, 1,4-Addition to Enones, etc.) to be performed in water.

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.