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725765

Sigma-Aldrich

2-Methyl-4-isothiazolin-3-one

95%

Synonyma:

2-Methyl-3(2H)-isothiazolone

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About This Item

Empirický vzorec (Hillův zápis):
C4H5NOS
Číslo CAS:
2682-20-4
Molekulová hmotnost:
115.15
Beilstein/REAXYS Number:
606203
EC Number:
220-239-6
MDL number:
MFCD01742315
UNSPSC Code:
12352100
PubChem Substance ID:
329764182
NACRES:
NA.21

assay

≥94.0% (GC)
95%

form

lumps

impurities

≤5% water

SMILES string

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3

InChI key

BEGLCMHJXHIJLR-UHFFFAOYSA-N

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Application

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.: This study investigates the differential sensitivity of daphnids to 2-Methyl-4-isothiazolin-3-one, highlighting the biochemical mechanisms underlying these variations. The findings provide crucial insights for environmental safety assessments (Kim et al., 2023).
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.: The study assesses the impact of 2-Methyl-4-isothiazolin-3-one on regenerative processes in amphibians, contributing to the understanding of its biological effects and potential toxicity (Delos Santos et al., 2016).
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.: This review includes discussions on 2-Methyl-4-isothiazolin-3-one-induced contact dermatitis, providing valuable information for dermatological applications and safety assessments (Knackstedt and Zug, 2015).

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

supp_hazards

EUH071

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Osvědčení o analýze (COA)

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Sigma-Aldrich

CDS003259

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5-Bromo-5-nitro-1,3-dioxane ≥99%

Sigma-Aldrich

B8791

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ProClin™ 950 pkg of 17 L, ProClin™ preservative for use in IVD manufacturing, MIT 9.5 %

Sigma-Aldrich

46884-U

ProClin™ 950

Juan García-Gavín et al.
Contact dermatitis, 63(2), 96-101 (2010-07-16)
A few cases on primary sensitization by, and occupational contact dermatitis from, methylisothiazolinone in paints and glues have been published. In cosmetics, methylisothiazoline (MI) is permitted in a concentration of 100 p.p.m., while 15 p.p.m. for the mixture of methylchloroisothiazolinone
Paula Maio et al.
Cutaneous and ocular toxicology, 31(2), 151-153 (2011-11-05)
Several preservatives are currently allowed in cosmetic products in the EU. However, only a few of them are strongly represented on the market: formaldehyde, parabens, formaldehyde releasers and methylchoroisothiazolinone/methylisothiazolinone (MCI/MI). MCI/MI has been widely used during recent years for the
Kevin H Gardner et al.
Archives of dermatology, 146(8), 886-890 (2010-06-23)
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), a common preservative in some brands of moist toilet paper (baby wipes and moist towelettes), has been reported to be a cause of allergic contact dermatitis. However, few cases have been reported in the United States. We report
Johannes Geier et al.
Contact dermatitis, 67(6), 334-341 (2012-09-22)
The frequency of sensitization to methylchloroisothiazolinone (MCI)/ methylisothiazolinone (MI) observed in the Information Network of Departments of Dermatology (IVDK) was constantly around 2.1% from 1998 to 2009. After that, it increased to 3.9% in 2011, paralleled by an increase in
Wolfgang Uter et al.
Contact dermatitis, 67(3), 125-129 (2012-05-09)
The preservative methylchloroisothiazolinone (MCI)/methylisothiazo- linone (MI) is an important allergen, and has thus been subject to regulation in some areas of exposure, mainly in cosmetics. To examine whether a decline in sensitization prevalence and intensity of elicitation (by the patch
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