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Merck

1029501

USP

Amlodipine besylate

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Amlodipine besylate, 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc

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About This Item

Fórmula empírica (notación de Hill):
C20H25ClN2O5 · C6H5SO3H
Número de CAS:
Peso molecular:
567.05
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
En este momento no podemos mostrarle ni los precios ni la disponibilidad

grado

pharmaceutical primary standard

familia API

amlodipine

fabricante / nombre comercial

USP

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC

InChI

1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

Clave InChI

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Información sobre el gen

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Amlodipine besylate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amlodipine and Atorvastatin Tablets
  • Amlodipine and Benazepril Hydrochloride Capsules
  • Amlodipine and Olmesartan Medoxomil Tablets
  • Amlodipine and Valsartan Tablets
  • Amlodipine Besylate
  • Amlodipine Besylate Tablets
  • Amlodipine Compounded Oral Suspension

Acciones bioquímicas o fisiológicas

Amlodipine besylate is an L-type calcium channel blocker.
Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
Precios

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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J M Krzesinski et al.
Revue medicale de Liege, 62(11), 688-694 (2008-01-26)
Hypertension is a common treatable risk factor for cardiovascular disease. Even when identified and treated, most patients with hypertension do not get to blood pressure goal and they often need at least two antihypertensive agents to achieve blood pressure control.
C Venkata S Ram
Expert review of cardiovascular therapy, 9(1), 9-19 (2010-12-21)
Hypertension is an increasingly prevalent cardiovascular risk factor associated with high rates of morbidity and mortality. Lowering blood pressure (BP) to recommended levels reduces the risk of hypertension-associated cardiovascular events. Despite current treatment options and recommendations, the BP of many
Amlodipine besylate.
Gennady Ananchenko et al.
Profiles of drug substances, excipients, and related methodology, 37, 31-77 (2012-04-04)
Rishi Puri et al.
Journal of the American College of Cardiology, 65(13), 1273-1282 (2015-04-04)
Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. This study compared changes in coronary atheroma volume and calcium indices
Eun Young Lee et al.
Rheumatology (Oxford, England), 53(4), 658-664 (2013-12-20)
RP is a reversible vasoconstriction of digital arteries that causes pain and skin discoloration. This study compared the efficacy of the new phosphodiesterase type 5 inhibitor udenafil with that of the calcium channel blocker amlodipine in the treatment of secondary

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